Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of...
[via Entrez PubMed]:Interesting article re a tyrosine kinase inhibitor Sugen is developing. I love to see real translational research, using patients' cells in trials and doing molecular assays for...
View ArticleFirst Dual inhibitor of AKT and S6K to Enter Clinical Development
   The compound, XL418 is an inhibitor of protein kinase B (PKB or AKT) and S6 Kinase (S6K), key components of the phosphoinosotide-3 kinase (PI3K) signaling pathway. Activation of these kinases...
View Article'Bridge' protein spurs deadliest stages of breast cancer
New role for protein yields promising lead for metastasistermterm prevention A protein known for its ability to "bridge" interactions between other cellular proteins may spur metastasis in breast...
View ArticleMolecular differences between early and advanced melanomas could provide new...
- Editors note. Akt is a target in a large number of metastaticterm cancers. The cell-signaling molecule Akt is a primary trigger that leads malignant melanomas on the skin's surface to begin...
View ArticleResearchers identify new, cancer-causing role for protein
HOUSTON - The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth, researchers at The...
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